ADM-Kaninchen-pAb von ELK Biotechnology
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ADM rabbit pAb ist ein Antikörper von ELK Biotechnology für Forschungsabläufe, die ADM betreffen.
Das von diesem Gen kodierte Protein ist ein Präprohormon, das in zwei biologisch aktive Peptide gespalten wird: Adrenomedullin und Proadrenomedullin N-terminales 20 Peptid. Adrenomedullin ist ein 52 Aminosäuren langes Peptid mit verschiedenen Funktionen, darunter Vasodilatation, Regulierung der Hormonsekretion, Förderung der Angiogenese und antimikrobielle Aktivität. Die antimikrobielle Aktivität ist antibakteriell, da das Peptid nachweislich E. coli und S. aureus bei niedriger Konzentration abtötet. [bereitgestellt von RefSeq, Aug 2014].
| Spezifität | ADM Polyclonal Antibody weist endogene ADM-Proteinspiegel nach. |
|---|---|
| Validierungsnachweisbeschriftungen | Western Blot-Analyse von Mausenieren-, Mauslungen-, Mausherzzellen unter Verwendung von ADM Polyclonal Antibody. Sekundärantikörper (Katalog-Nr.: RS0002) wurde 1:20000 verdünnt | Immunhistochemische Analyse von paraffineingebetteter menschlicher Leber, Antikörper wurde 1:100 verdünnt | Immunhistochemische Analyse von paraffineingebetteter menschlicher Leber, Antikörper wurde 1:100 verdünnt | Immunhistochemische Analyse von paraffineingebetteter Rattenniere, Antikörper wurde 1:100 verdünnt |
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Mensch | |||||||
| Ratte |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Adrenomedullin (ADM; AM) is produced from the pro-adrenomedullin precursor, which also gives rise to proadrenomedullin N-terminal peptide (PAMP). Human ADM is represented by NCBI Gene 133 and reviewed UniProtKB P35318, with related ABMIUM catalogue reagents for research use.
Biological function: The ADM gene encodes pro-adrenomedullin, a precursor processed into biologically active peptides including adrenomedullin and PAMP. Curated NCBI and UniProt records describe adrenomedullin as a vasoactive peptide with potent vasodilatory and hypotensive activity and roles in fluid and electrolyte homeostasis; reviewed UniProt identifies signalling through CALCRL-RAMP2 and CALCRL-RAMP3 receptor complexes.
