BACE (Phospho Ser498) Kaninchen-pAb von ELK Biotechnology
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BACE (Phospho Ser498) rabbit pAb ist ein ELK Biotechnology Antikörper für Forschungsabläufe, die BACE betreffen.
Beta-Sekretase 1 (BACE1) Homo sapiens Dieses Gen kodiert für ein Mitglied der Peptidase A1-Familie der Aspartatproteasen. Alternatives Spleißen führt zu mehreren Transkriptvarianten, von denen mindestens eine ein Präproprotein kodiert, das proteolytisch verarbeitet wird, um die reife Protease zu erzeugen. Diese Transmembranprotease katalysiert den ersten Schritt bei der Bildung von Amyloid-beta-Peptid aus Amyloid-Vorläuferprotein. Amyloid-beta-Peptide sind der Hauptbestandteil von Amyloid-beta-Plaques, die sich in den Gehirnen von Alzheimer-Patienten ansammeln. [bereitgestellt von RefSeq, Nov 2015]
| Spezifität | Dieser Antikörper detektiert endogene Spiegel von humanem, Maus-, Ratten-BACE (Phospho Ser498) |
|---|---|
| Nachweisnachweise (Bildunterschriften) | Western Blot Analyse von Hela, behandelt oder unbehandelt mit LPS-Lyse, unter Verwendung des primären Antikörpers in einer Verdünnung von 1:1000. Der sekundäre Antikörper (Katalognummer: RS23920) wurde 1:10000 verdünnt. |
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IF | ELISA | IP | FCM | ChIP |
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| Mensch | |||||||
| Maus | |||||||
| Ratte |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Beta-secretase 1 (BACE1), also known as BACE, is a membrane aspartyl protease best known for initiating beta-site processing of amyloid precursor protein (APP). This target page groups ABMIUM catalogue reagents for studying APP proteolysis, amyloid-beta pathway biology and BACE1-dependent neuronal protein processing.
Biological function: BACE1 is a type I transmembrane aspartyl protease. It cleaves APP at the beta-secretase site, generating the C99 fragment that can be further processed by gamma-secretase to produce amyloid-beta peptides. BACE1 activity is favoured in acidic intracellular compartments such as endosomes, and the enzyme also processes additional neuronal membrane proteins.
