Bcl-Xl Kaninchen-pAk von ELK Biotechnology
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Bcl-Xl Kaninchen-pAk ist ein Antikörper von ELK Biotechnology für Forschungsabläufe, die Bcl-Xl betreffen.
Bcl-xL verhindert Apoptose durch zwei verschiedene Mechanismen: Heterodimerisierung mit einem apoptotischen Protein hemmt dessen apoptotische Wirkung und die Bildung von Poren in der äußeren Mitochondrienmembran hilft, unter Stressbedingungen einen normalen Membranzustand aufrechtzuerhalten.
| Validierungsnachweisbeschriftungen | Immunhistochemische Analyse von in Paraffin eingebettetem menschlichem Lungenkarzinom unter Verwendung von Bcl-Xl(EA258) Kaninchen-pAk, verdünnt auf 1:200. |
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Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Mensch | |||||||
| Ratte | |||||||
| Maus |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
BCL2 like 1 (BCL2L1) encodes Bcl-2-like protein 1, whose major splice isoforms include anti-apoptotic Bcl-xL and pro-apoptotic Bcl-xS. This BCL-2-family regulator is central to mitochondrial apoptosis and cell-survival research.
Biological function: BCL2L1 produces Bcl-2-like protein 1 isoforms with opposing effects on apoptosis. Bcl-xL inhibits cell death by limiting mitochondrial cytochrome-c release and caspase activation, whereas Bcl-xS promotes apoptosis. The reviewed human protein is also implicated in cell-cycle checkpoint regulation.
