MEK1 Kaninchen-pAk von ELK Biotechnology
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MEK1 Kaninchen-pAk ist ein ELK Biotechnology-Antikörper für Forschungsabläufe, die MEK1 betreffen.
MEK1 und MEK2, auch als MAPK- oder Erk-Kinasen bezeichnet, sind dual-spezifische Proteinkinasen, die in einer mitogen-aktivierten Proteinkinase-Kaskade wirken, die Zellwachstum und -differenzierung steuert. Katalysiert die gleichzeitige Phosphorylierung eines Threonin- und eines Tyrosinrestes in einer Thr-Glu-Tyr-Sequenz, die in MAP-Kinasen lokalisiert ist. Aktiviert ERK1 und ERK2 MAP-Kinasen.
| Validierungsnachweisbeschriftungen | Western-Blot-Analyse von 1) Hela, 2) 3T3, 3) PC12 mit MEK1 Kaninchen-pAk EA219 verdünnt im Verhältnis 1:2.000. | Immunhistochemische Analyse von paraffin-eingebettetem menschlichem Kolonkarzinom unter Verwendung von MEK1 (EA219) Kaninchen-pAk, verdünnt im Verhältnis 1:200. | Western-Blot-Analyse von Extrakten aus MG63 (Spur 1), MCF-7 (Spur 2), 3T3 (Spur 3), Rattenniere (Spur 4), unter Verwendung von MEK1, verdünnt im Verhältnis 1:50.000. |
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Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Mensch | |||||||
| Ratte | |||||||
| Maus |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
MAP2K1 identifies mitogen-activated protein kinase kinase 1 in Homo sapiens (Human). This target record connects NCBI Gene 5604, UniProtKB Q02750 and related ABMIUM catalogue products.
Biological function: Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1; MEK1/MKK1) is a dual-specificity kinase in the RAS-RAF-MEK-ERK pathway. It phosphorylates and activates ERK1/ERK2, coupling upstream growth-factor signals to cellular proliferation, differentiation and survival programs.
