ELISA-Kit geliefert von Boster Bio
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Interleukin-1β (IL-1β) ist ein potenter Stimulator der Knochenresorption, dessen Gen auf 2q14 kartiert ist und der an der Pathogenese von hohem Knochenumsatz und Osteoporose beteiligt ist. IL-1β, ein prominentes, von Mikroglia stammendes Zytokin, verursachte den Tod von Oligodendrozyten in Kokulturen mit Astrozyten und Mikroglia, jedoch nicht in Reinkulturen von Oligodendrozyten allein. Es kann auch den nukleären Export eines spezifischen NCOR-Korepressorkomplexes verursachen, was zu einer Derepression einer spezifischen Untergruppe von Kernfaktor-kappa-B (NFKB)-regulierten Genen führt. Darüber hinaus sind mikroenvironmentales IL-1β und, in geringerem Maße, IL-1α für die In-vivo-Angiogenese und Invasivität verschiedener Tumorzellen erforderlich. Zusätzlich induziert die Kooperation von IL-1β und PDGFB eine kontraktile zu synthetische Phänotypmodifikation von humanen aortalen glatten Muskelzellen in Kultur. Des Weiteren kann die Assoziation mit Krankheiten durch die biologischen Eigenschaften von IL-1β erklärt werden, welches ein wichtiges proinflammatorisches Zytokin und ein starker Inhibitor der Magensäuresekretion ist.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Sample compatibility evidence using the same validation key.
| Sample type | Probenkompatibilität | Assay-Bereich | Sensitivität | Spezifität |
|---|---|---|---|---|
| Zellkulturüberstände | ||||
| Serum | ||||
| Plasma (Heparin | ||||
| EDTA) |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
IL1B identifies interleukin 1 beta in Homo sapiens (Human). This target record connects NCBI Gene 3553, UniProtKB P01584 and related ABMIUM catalogue products.
Biological function: IL1B encodes interleukin-1 beta, a potent pro-inflammatory cytokine that promotes innate and adaptive immune responses including neutrophil activation, T- and B-cell activation and Th17 differentiation. Mature IL-1 beta can also be released during pyroptotic inflammation.
