Primary Antibodie supplied by Boster Bio.
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Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic pattern specification and intracellular signal transduction. Acts upstream of with a positive effect on nodal signaling pathway. Acts upstream of or within several processes, including convergent extension involved in axis elongation; negative regulation of signal transduction; and positive regulation of oocyte development. Is active in chromatin and nucleus. Is expressed in brain; head; heart; immature eye; and tail bud. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 6; Lynch syndrome; cervical cancer; and ovarian cancer. Orthologous to human SMAD2 (SMAD family member 2).
Product profile: Reactivity: Zebrafish; Host: Rabbit; Clonality: Polyclonal; Isotype: Rabbit IgG.
Applications: WB.
Recommended conditions: Western blot, 0.25-0.5 μg/ml, Zebrafish<br>
Technical details: Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of zebrafish SMAD2.(SEIWGLSTPNTIEQWDTSG).; Purification: Immunogen affinity purified.; Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.; Observed MW: 52 kDa; Calculated MW: 52 kDa.
Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.
Research Use Only.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species | WB | IHC | IHC-P | IHC-F | IF/ICC | Flow Cytometry | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Zebrafish |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
SMAD2 identifies SMAD family member 2 in Homo sapiens (Human). This target record connects NCBI Gene 4087, UniProtKB Q15796 and related ABMIUM catalogue products.
Biological function: SMAD family member 2 (SMAD2; MADH2) is a receptor-regulated SMAD transcriptional mediator in transforming growth factor beta (TGF-beta) and activin signalling. Activated type I receptors phosphorylate SMAD2, enabling complexes with SMAD4 that regulate target-gene transcription.
