Primärantikörper geliefert von Boster Bio
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Das TNF-alpha-Gen (Tumor-Nekrose-Faktor alpha) kodiert ein multifunktionales proinflammatorisches Zytokin, das zur Tumornekrosefaktor (TNF)-Superfamilie gehört. Dieses Zytokin wird hauptsächlich von Makrophagen sezerniert. Es kann an seine Rezeptoren TNFRSF1A/TNFR1 und TNFRSF1B/TNFBR binden und wirkt somit über diese. Dieses Zytokin ist an der Regulation eines breiten Spektrums biologischer Prozesse beteiligt, einschließlich Zellproliferation, Differenzierung, Apoptose, Lipidstoffwechsel und Koagulation. Dieses Zytokin wurde in eine Vielzahl von Krankheiten, einschließlich Autoimmunerkrankungen, Insulinresistenz und Krebs, involviert. Knockout-Studien an Mäusen deuteten auch auf die neuroprotektive Funktion dieses Zytokins hin.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Mouse |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
TNF encodes a multifunctional pro-inflammatory cytokine in the tumour necrosis factor superfamily. This target hub connects accepted names and identifiers with ABMIUM antibodies, ELISA kits and related assay products.
Biological function: TNF is produced as a membrane-associated cytokine and can be released in soluble form. Signalling through TNFRSF1A (TNFR1) and TNFRSF1B (TNFR2) contributes to regulation of inflammation, immune responses, cell survival, differentiation and cell death.
