Primärantikörper geliefert von Boster Bio
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Der Transformierende Wachstumsfaktor, Beta-Rezeptor I, ist ein TGF-Beta-Rezeptor. TGFBR1 ist sein menschliches Gen. Das von diesem Gen kodierte Protein bildet einen heteromeren Komplex mit Typ-II-TGF-Beta-Rezeptoren, wenn es an TGF-Beta gebunden ist, und leitet das TGF-Beta-Signal von der Zelloberfläche ins Zytoplasma. Mutationen in diesem Gen wurden mit dem Loeys-Dietz-Aortenaneurysma-Syndrom (LDAS) in Verbindung gebracht. TGFB1 reguliert den Zellzyklusfortschritt durch einen einzigartigen Signalmechanismus, der seine Bindung an TGFBR2 und die Aktivierung von TGFBR1 beinhaltet. Beide sind Transmembran-Serin/Threonin-Rezeptorkinasen. Der TGFBR1-Rezeptor kann in vielen Fällen menschlicher Tumorzellen, die gegenüber dem TGFB-vermittelten Zellzyklusarrest refraktär sind, inaktiviert sein.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human | ||||||||
| Mouse | ||||||||
| Rat |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
TGFBR1 identifies transforming growth factor beta receptor 1 in Homo sapiens (Human). This target record connects NCBI Gene 7046, UniProtKB P36897 and related ABMIUM catalogue products.
