Primärantikörper geliefert von Boster Bio
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Der Rezeptor für fortgeschrittene Glykationsendprodukte (RAGE) ist ein Multiliganden-Mitglied der Immunglobulin-Superfamilie von Zelloberflächenmolekülen. Er interagiert mit verschiedenen Molekülen, die an Homöostase, Entwicklung und Entzündung sowie an bestimmten Krankheiten wie Diabetes und Alzheimer-Krankheit beteiligt sind. RAGE ist auch ein zentraler Zelloberflächenrezeptor für Amphoterin und EN-RAGE. RAGE ist mit einer anhaltenden NF-kappaB-Aktivierung im diabetischen Mikromilieu verbunden und spielt eine zentrale Rolle bei der sensorischen neuronalen Dysfunktion. Darüber hinaus fördert RAGE die zelluläre Dysfunktion bei mehreren entzündlichen Erkrankungen und Diabetes und fungiert auch als endothelialer Adhäsionsrezeptor, der die Rekrutierung von Leukozyten fördert.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human | ||||||||
| Maus | ||||||||
| Ratte |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
AGER is the advanced glycosylation end-product specific receptor, commonly known as RAGE. It is a multiligand cell-surface receptor that senses advanced glycation end products and other endogenous stress-associated ligands, linking extracellular stress signals to inflammatory cellular responses.
Biological function: AGER/RAGE is an immunoglobulin-superfamily pattern-recognition receptor that binds multiple structurally diverse ligands, including advanced glycation end products, S100 proteins and HMGB1. Ligand engagement activates intracellular signalling programmes that can include NF-kappa-B and other inflammatory pathways, allowing cells to respond to tissue stress and damage-associated signals.
