Primärantikörper geliefert von Boster Bio
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Mothers against decapentaplegic homolog 7 oder SMAD7 ist ein Protein, das beim Menschen durch das Gen SMAD7 kodiert wird. Das durch dieses Gen kodierte Protein ist ein nukleäres Protein, das die E3-Ubiquitinligase SMURF2 bindet. Nach der Bindung transloziert dieser Komplex in das Zytoplasma, wo er mit dem TGF-beta-Rezeptor Typ 1 (TGFBR1) interagiert, was zum Abbau sowohl des kodierten Proteins als auch von TGFBR1 führt. Die Expression dieses Gens wird durch TGFBR1 induziert. Variationen in diesem Gen sind eine Ursache für die Anfälligkeit für Darmkrebs Typ 3 (CRCS3). Für dieses Gen wurden mehrere Transkriptvarianten gefunden, die verschiedene Isoformen kodieren.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human | ||||||||
| Mouse | ||||||||
| Rat |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
