Primärantikörper von Boster Bio
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Tyrosin-Proteinkinase JAK3 ist ein Enzym, das beim Menschen durch das JAK3-Gen kodiert wird. Es ist auf 19p13.11 kartiert. Das von diesem Gen kodierte Protein gehört zur Januskinase (JAK)-Familie von Tyrosinkinasen, die an der Zytokinrezeptor-vermittelten intrazellulären Signaltransduktion beteiligt sind. Es wird überwiegend in Immunzellen exprimiert und leitet ein Signal als Reaktion auf seine Aktivierung durch Tyrosinphosphorylierung durch Interleukinrezeptoren weiter. Mutationen in diesem Gen sind mit autosomalem SCID (schwerer kombinierter Immundefizienz) verbunden.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
JAK3 identifies Janus kinase 3 in Homo sapiens (Human). This target record connects NCBI Gene 3718, UniProtKB P52333 and related ABMIUM catalogue products.
