Primärantikörper geliefert von Boster Bio
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ITCH ist ein Ubiquitin-konjugierendes Enzym. Dieses Gen kodiert ein Mitglied der Nedd4-Familie der HECT-Domänen-E3-Ubiquitin-Ligasen. HECT-Domänen-E3-Ubiquitin-Ligasen übertragen Ubiquitin von E2-Ubiquitin-konjugierenden Enzymen auf Proteinsubstrate, wodurch spezifische Proteine für den lysosomalen Abbau markiert werden. Das kodierte Protein spielt eine Rolle bei mehreren zellulären Prozessen, einschließlich der Differenzierung erythroidaler und lymphoider Zellen und der Regulierung von Immunantworten. Mutationen in diesem Gen sind eine Ursache für syndromische Multisystem-Autoimmunerkrankungen. Alternativ gespleißte Transkriptvarianten, die mehrere Isoformen kodieren, wurden für dieses Gen beobachtet.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human | ||||||||
| Mouse | ||||||||
| Rat |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
ITCH identifies itchy E3 ubiquitin protein ligase in Homo sapiens (Human). This target record connects NCBI Gene 83737, UniProtKB Q96J02 and related ABMIUM catalogue products.
