Primärantikörper geliefert von Boster Bio
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Interleukin-6 (IL-6) ist ein Protein, das beim Menschen durch das IL6-Gen kodiert wird. IL-6 ist ein Interleukin, das sowohl als pro-inflammatorisches als auch als anti-inflammatorisches Zytokin wirkt. Es wird von T-Zellen und Makrophagen sezerniert, um die Immunantwort auf Traumata zu stimulieren, insbesondere auf Verbrennungen oder andere Gewebeschäden, die zu Entzündungen führen. IL-6 ist einer der wichtigsten Mediatoren von Fieber und der Akutphasenreaktion. IL-6 ist auch essenziell für das Hybridomawachstum und ist in vielen ergänzenden Klonierungsmedien wie Briclone enthalten. Bowcock et al. (1988) ordneten das IL6-Gen dem Chromosom 7p21 zu. Durch In-situ-Hybridisierung und Southern-Blot-Analyse von Maus-Mensch-Hybridzelllinien kartierten Sutherland et al. (1988) das IL-6-Gen auf Chromosom 7p15.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
IL6 encodes interleukin 6, a pleiotropic cytokine involved in immune signalling and acute-phase biology. This target hub connects verified human identifiers and aliases with ABMIUM antibodies, ELISA kits, proteins and related assay products.
Biological function: IL6 is a pleiotropic cytokine involved in immunity, tissue regeneration and metabolism. It binds IL6R and recruits the signalling subunit IL6ST/gp130 to activate IL6 pathways. IL6 can signal through membrane-bound IL6R (classic signalling) or soluble IL6R (trans-signalling), and it is a potent inducer of the acute-phase response.
