Primärantikörper geliefert von Boster Bio
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Das Rho-GTPase-aktivierende Protein 26 (ARHGAP26), auch bekannt als GTPase Regulator Associated with Focal Adhesion Kinase (GRAF), ist ein Protein, das beim Menschen durch das ARHGAP26-Gen kodiert wird. Die Interaktion einer Zelle mit der extrazellulären Matrix löst Integrin-Oberflächenrezeptoren aus, um Signalkaskaden zu starten, die die Organisation des Aktin-Zytoskeletts regulieren. Eines der an diesen Kaskaden beteiligten Proteine ist die Fokaladhäsionskinase. Das von diesem Gen kodierte Protein ist ein GTPase-aktivierendes Protein, das an die Fokaladhäsionskinase bindet und die Aktivität der GTP-bindenden Proteine RhoA und Cdc42 vermittelt. Defekte in diesem Gen sind eine Ursache für die juvenile myelomonozytäre Leukämie (JMML). Für dieses Gen wurden mehrere Transkriptvarianten gefunden, die verschiedene Isoformen kodieren.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human | ||||||||
| Mouse | ||||||||
| Rat |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.