Primärantikörper geliefert von Boster Bio
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Das Gen kodiert für ein Rab7-Adapterprotein, das am Mikrotubuli-Transport von Autophagosomen beteiligt ist. Das kodierte Protein enthält eine RUN-Domäne, eine FYVE-Typ-Zinkfingerdomäne und eine Golgi-Dynamik-Domäne (GOLD). Das kodierte Protein spielt eine Rolle beim Mikrotubuli-Plus-Ende-gerichteten Transport von autophagischen Vesikeln durch Wechselwirkungen mit der kleinen GTPase Rab7, Phosphatidylinositol-3-phosphat (PI3P), dem Autophagosom-Marker LC3 und dem Kinesin KIF5. Mutationen in diesem Gen sind mit der Einschlusskörpermyositis (IBM) und autosomal-rezessiven kongenitalen Katarakten (CATC2) assoziiert.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human | ||||||||
| Mouse | ||||||||
| Rat |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.