Primärantikörper geliefert von Boster Bio
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Die Langketten-Fettsäure-CoA-Ligase 4 ist ein Enzym, das beim Menschen durch das ACSL4-Gen kodiert wird. Es ist auf Xq23 kartiert. Das durch dieses Gen kodierte Protein ist ein Isoenzym der Langketten-Fettsäure-Coenzym-A-Ligase-Familie. Obwohl sie sich in Substratspezifität, subzellulärer Lokalisation und Gewebeverteilung unterscheiden, wandeln alle Isoenzyme dieser Familie freie Langketten-Fettsäuren in Fettsäureacyl-CoA-Ester um und spielen dadurch eine Schlüsselrolle bei der Lipidbiosynthese und dem Fettsäureabbau. Dieses Isoenzym verwendet bevorzugt Arachidonat als Substrat. Das Fehlen dieses Enzyms kann zur kognitiven Beeinträchtigung oder zum Alport-Syndrom beitragen. Alternatives Spleißen dieses Gens erzeugt mehrere Transkriptvarianten.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human | ||||||||
| Maus | ||||||||
| Ratte |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Acyl-CoA synthetase long chain family member 4 (ACSL4), also known as FACL4 and long-chain-fatty-acid--CoA ligase 4, activates long-chain fatty acids to acyl-CoA esters. Human ACSL4 maps to NCBI Gene 2182 and reviewed UniProtKB O60488; this record links the verified target to related ABMIUM catalogue products.
Biological function: ACSL4 catalyses activation of long-chain fatty acids to fatty acyl-CoA esters for cellular lipid synthesis and fatty-acid degradation. NCBI and reviewed UniProt describe a preference for arachidonate; UniProt also identifies ACSL4 as a ferroptosis activator by generating activated polyunsaturated-fatty-acid substrates that can undergo lipid peroxidation.
