Primärantikörper geliefert von Boster Bio
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Keratin, Typ I zytoskelettal 19 ist ein Protein, das beim Menschen durch das KRT19-Gen kodiert wird. Das durch dieses Gen kodierte Protein gehört zur Keratinfamilie. Es wird spezifisch im Periderm exprimiert, der vorübergehend oberflächlichen Schicht, die die sich entwickelnde Epidermis umhüllt. Die Zytokeratine vom Typ I sind in einer Region des Chromosoms 17q12-q21 geclustert. Aufgrund seiner hohen Sensitivität ist KRT19 der am häufigsten verwendete Marker für den RT-PCR-vermittelten Nachweis von Tumorzellen, die in Lymphknoten, peripherem Blut und Knochenmark von Brustkrebspatientinnen disseminiert sind. Keratin 19 wird häufig zusammen mit Keratin 8 und Keratin 18 verwendet, um Zellen epithelialen Ursprungs von hämatopoetischen Zellen in Tests zu unterscheiden, die zirkulierende Tumorzellen im Blut zählen.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
KRT19 identifies keratin 19 in Homo sapiens (Human). This target record connects NCBI Gene 3880, UniProtKB P08727 and related ABMIUM catalogue products.
