Primärantikörper geliefert von Boster Bio
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Kollagen, Typ II, Alpha 1 (primäre Osteoarthritis, Spondyloepiphysäre Dysplasie, kongenital), auch bekannt als COL2A1, ist ein menschliches Gen, das Anweisungen für die Produktion der Pro-Alpha1(II)-Kette von Typ-II-Kollagen liefert. Dieses Gen kodiert die Alpha-1-Kette von Typ-II-Kollagen, einem fibrillären Kollagen, das in Knorpel und dem Glaskörper des Auges vorkommt. Mutationen in diesem Gen sind mit Achondrogenese, Chondrodysplasie, früh einsetzender familiärer Osteoarthritis, SED congenita, Langer-Saldino Achondrogenese, Kniest-Dysplasie, Stickler-Syndrom Typ I und spondyloepimetaphysärer Dysplasie vom Strudwick-Typ assoziiert. Darüber hinaus sind Defekte bei der Verarbeitung von Chondrocalcin, einem kalziumbindenden Protein, das das C-Propeptid dieses Kollagenmoleküls ist, ebenfalls mit Chondrodysplasie assoziiert. Für dieses Gen sind zwei Transkripte identifiziert.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human | ||||||||
| Mouse | ||||||||
| Rat |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
COL2A1 identifies collagen type II alpha 1 chain in Homo sapiens (Human). This target record connects NCBI Gene 1280, UniProtKB P02458 and related ABMIUM catalogue products.
