Primärantikörper geliefert von Boster Bio
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Das CD8-Antigen ist ein Zelloberflächenglykoprotein, das auf den meisten zytotoxischen T-Lymphozyten vorkommt und effiziente Zell-Zell-Interaktionen innerhalb des Immunsystems vermittelt. Es ist auf 2p11.2 kartiert. Das CD8-Antigen, das als Korezeptor fungiert, und der T-Zell-Rezeptor auf dem T-Lymphozyten erkennen Antigene, die von einer Antigen-präsentierenden Zelle (APC) im Kontext von Klasse-I-MHC-Molekülen präsentiert werden. Der funktionelle Korezeptor ist entweder ein Homodimer, das aus zwei Alpha-Ketten besteht, oder ein Heterodimer, das aus einer Alpha- und einer Beta-Kette besteht. Sowohl Alpha- als auch Beta-Ketten weisen eine signifikante Homologie zu Immunglobulin-Variablen-Leichtketten auf. Dieses Gen kodiert auch die CD8-Alpha-Kettenisoformen.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
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| Ratte |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
CD8 subunit alpha (CD8A), also known as CD8 alpha and T-cell surface glycoprotein CD8 alpha chain, is a T-cell coreceptor protein. This guide connects human NCBI Gene 925, UniProtKB P01732 and ABMIUM catalogue products associated with CD8A.
Biological function: CD8 alpha is a cell-surface glycoprotein expressed on many cytotoxic T lymphocytes and functions as a coreceptor with the T-cell receptor during recognition of antigen presented by MHC class I molecules. CD8A can form alpha-alpha homodimers or alpha-beta heterodimers with CD8B.
