Primärantikörper geliefert von Boster Bio
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Das B-Lymphozyten-Antigen CD19, auch bekannt als CD19 (Cluster of Differentiation 19), ist ein Protein, das beim Menschen durch das CD19-Gen kodiert wird. Es befindet sich auf der Oberfläche von B-Zellen, einer Art weißer Blutkörperchen. Lymphozyten proliferieren und differenzieren sich als Reaktion auf verschiedene Konzentrationen unterschiedlicher Antigene. Die Fähigkeit der B-Zelle, spezifisch und dennoch empfindlich auf die verschiedenen Antigene zu reagieren, wird durch die Verwendung von Antigenrezeptoren mit geringer Affinität erreicht. Das CD19-Gen kodiert ein Zelloberflächenmolekül, das sich mit dem Antigenrezeptor von B-Lymphozyten verbindet, um die Schwelle für die Antigenrezeptor-abhängige Stimulation zu senken.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Rat |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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CD19 molecule (CD19), also known as B-lymphocyte antigen CD19, is a B-cell surface glycoprotein and signalling coreceptor. This guide connects human NCBI Gene 930, UniProtKB P15391 and ABMIUM catalogue products associated with CD19.
Biological function: CD19 functions as a coreceptor for the B-cell antigen receptor complex, lowering the threshold for antigen-triggered B-cell activation. CD19 signalling can activate phosphatidylinositol 3-kinase pathways and mobilise intracellular calcium, supporting normal B-cell differentiation, proliferation and antibody responses.
