Primärantikörper geliefert von Boster Bio
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Das von diesem Gen kodierte Protein ist eine lysosomale Cysteinproteinase, die eine wichtige Rolle beim intrazellulären Proteinkatabolismus spielt. Zu ihren Substraten gehören Kollagen und Elastin sowie Alpha-1-Protease-Inhibitor, ein wichtiges Kontrollelement der neutrophilen Elastaseaktivität. Das kodierte Protein wurde in mehreren pathologischen Prozessen nachgewiesen, darunter Myofibrillennekrose bei Myopathien und bei Myokardischämie sowie bei der renalen Tubulusreaktion auf Proteinurie. Dieses Protein, das zur Peptidase-C1-Familie gehört, ist ein Dimer, das aus Disulfid-verknüpften schweren und leichten Ketten besteht, die beide aus einem einzigen Proteinvorläufer produziert werden. Zusätzlich spaltet dieses Protein die S1-Untereinheit des SARS-CoV-2-Spike-Proteins, was für das Eindringen des Virus in die Zelle notwendig ist.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Maus | ||||||||
| Ratte |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
CTSL identifies cathepsin L in Homo sapiens (Human). This target record connects NCBI Gene 1514, UniProtKB P07711 and related ABMIUM catalogue products.
Biological function: Cathepsin L (CTSL; cathepsin L1/CTSL1) is a lysosomal cysteine protease that degrades proteins within endolysosomal compartments and contributes to antigen processing and broader intracellular and extracellular protein turnover.
