Primärantikörper geliefert von Boster Bio
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APOE ist auch bekannt als AD2 oder LPG. Das von diesem Gen kodierte Protein ist ein Hauptapoprotein des Chylomikrons. Es bindet an einen spezifischen Leber- und peripheren Zellrezeptor und ist essenziell für den normalen Katabolismus von triglyzeridreichen Lipoproteinbestandteilen. Dieses Gen befindet sich auf Chromosom 19 in einem Cluster mit den verwandten Apolipoprotein-C1- und C2-Genen. Mutationen in diesem Gen führen zu familiärer Dysbetalipoproteinämie oder Typ-III-Hyperlipoproteinämie (HLP III), bei der erhöhte Plasmacholesterin- und Triglyzeridwerte die Folge einer gestörten Clearance von Chylomikron- und VLDL-Resten sind. Alternatives Spleißen führt zu mehreren Transkriptvarianten.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Maus | ||||||||
| Ratte |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Apolipoprotein E (APOE, ApoE) is a lipid-binding apolipoprotein that supports transport, uptake and clearance of lipoprotein-associated lipids. ABMIUM catalogue products linked below support research on APOE biology.
Biological function: Apolipoprotein E (APOE/ApoE) is a major apolipoprotein involved in lipoprotein-mediated lipid transport between tissues. It associates with several classes of circulating lipoproteins, binds receptors including LDL receptor family members and contributes to lipoprotein clearance, cholesterol transport and broader lipid homeostasis. APOE also has important roles in lipid transport within the central nervous system.
