Primärantikörper geliefert von Boster Bio
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Anti-Müllerian-Hormon (AMH), auch bekannt als MIF oder MIS, ist ein Protein, das beim Menschen durch das AMH-Gen kodiert wird. Es ist ein Hormon, das die Entwicklung der Müller-Gänge (Paramesonephric Gänge) im männlichen Embryo hemmt. Die Expression von AMH wird durch SOX9 in den männlichen Sertoli-Zellen aktiviert und bewirkt die irreversible Rückbildung der Müller-Gänge. Da die AMH-Expression für die Geschlechtsdifferenzierung zu einem bestimmten Zeitpunkt der fötalen Entwicklung entscheidend ist, scheint sie durch SF1, GATA-Faktoren, DAX1 und FSH streng reguliert zu werden. Dieses Protein spielt auch eine Rolle bei der Leydig-Zell-Differenzierung und -Funktion sowie bei der Follikelentwicklung bei erwachsenen Frauen. Mutationen in diesem Gen führen zum persistenten Müller-Gang-Syndrom.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human |
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AMH (anti-Mullerian hormone; anti-Muellerian hormone) is a secreted TGF-beta-superfamily ligand also known as Mullerian-inhibiting substance (MIS). It signals through AMHR2 and downstream SMAD pathways in reproductive development and gonadal biology.
Biological function: AMH is synthesized as a preproprotein and proteolytically processed into an active ligand complex. It binds the type-II receptor AMHR2, which recruits type-I receptors including ACVR1 and BMPR1A to activate SMAD signalling. During male fetal development this pathway drives Mullerian duct regression; AMH also contributes to Leydig-cell and ovarian follicle biology.
