Primärantikörper geliefert von Boster Bio
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Protein AMBP ist ein Protein, das beim Menschen durch das AMBP-Gen kodiert wird. Dieses Gen kodiert ein komplexes Glykoprotein, das im Plasma ausgeschieden wird. Der Vorläufer wird proteolytisch in unterschiedliche funktionierende Proteine zerlegt: Alpha-1-Mikroglobulin, das zur Superfamilie der Lipocalin-Transportproteine gehört und eine Rolle bei der Regulierung von Entzündungsprozessen spielen könnte, und Bikunin, das ein Harn-Trypsin-Inhibitor ist, der zur Superfamilie der Kunitz-Typ-Proteaseinhibitoren gehört und eine wichtige Rolle bei vielen physiologischen und pathologischen Prozessen spielt. Dieses Gen befindet sich auf Chromosom 9 in einem Cluster von Lipocalin-Genen.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
AMBP (alpha-1-microglobulin/bikunin precursor) is a secreted precursor processed into alpha-1-microglobulin (A1M), an antioxidative lipocalin, and bikunin, a serine-protease inhibitor. It is studied in extracellular oxidative-stress control, protease regulation and inter-alpha-inhibitor biology.
Biological function: Proteolytic processing of AMBP produces two functionally distinct proteins. Alpha-1-microglobulin binds and scavenges heme and reactive radicals and contributes to protection from oxidative tissue damage. Bikunin inhibits several serine proteases and contributes to inter-alpha-trypsin inhibitor family complexes in extracellular protease regulation.
