Primärantikörper geliefert von Boster Bio
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AFP, auch Alpha-Fetoprotein genannt, ist ein Protein, das beim Menschen durch das AFP-Gen kodiert wird. Es ist auf 4q13.3 kartiert. Der AFP-Spiegel im Fruchtwasser wird verwendet, um den renalen Proteinverlust zu messen und Spina bifida und Anenzephalie zu screenen. Bei Nagetieren bindet AFP Östradiol, um den Transport dieses Hormons über die Plazenta zum Fötus zu verhindern. Die Hauptfunktion besteht darin, die Virilisierung weiblicher Föten zu verhindern. Darüber hinaus spielt es eine wichtige Rolle als diagnostischer Marker, insbesondere bei bestimmten Tumoren und Lebererkrankungen im Kindesalter. AFP wird auch verwendet, um die potenzielle Nützlichkeit der Plasma-Alpha-Fetoprotein-Bestimmung als diagnostischen Marker bei Gallengangsatresie, Hepatitis und Dottersack-Tumoren zu testen.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
AFP (alpha fetoprotein; alpha-fetoprotein) encodes a major fetal plasma protein produced predominantly by the yolk sac and fetal liver. An albumin-family protein, AFP binds fatty acids, bilirubin and several metal ions and is widely studied in fetal development and liver biology.
Biological function: Alpha-fetoprotein (AFP) is a secreted fetal plasma protein structurally related to serum albumin. It binds fatty acids, bilirubin, copper and nickel and functions as a carrier protein during fetal life, with high production by the yolk sac and fetal liver before expression falls after birth.
