Primärantikörper geliefert von Boster Bio
Know who made it. See the evidence. Buy through one marketplace.
Dieses Gen kodiert für ein Mitglied der Argonaute-Proteinfamilie, die mit kleinen RNAs assoziiert sind und wichtige Rollen bei der RNA-Interferenz (RNAi) und der RNA-Stilllegung spielen. Dieses Protein bindet an microRNAs (miRNAs) oder kleine interferierende RNAs (siRNAs) und unterdrückt die Translation von mRNAs, die zu ihnen komplementär sind. Es ist auch an der transkriptionellen Gen-Stilllegung (TGS) von Promotorregionen beteiligt, die zu gebundenen kurzen Antigen-RNAs (agRNAs) komplementär sind, sowie am Abbau von miRNA-gebundenen mRNA-Zielen. Alternativ gespleißte Transkriptvarianten, die verschiedene Isoformen kodieren, wurden für dieses Gen gefunden. Eine aktuelle Studie zeigte, dass dieses Gen ein authentisches Stopcodon-Readthrough-Ziel ist und dass seine mRNA durch die Verwendung eines alternativen In-Frame-Translations-Terminationscodons zu einer zusätzlichen C-terminal verlängerten Isoform führen könnte.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
AGO1 (argonaute RISC component 1; protein argonaute-1) is an Argonaute-family RNA-binding protein that uses small regulatory RNAs to guide gene silencing. It is studied as a core component of miRNA- and siRNA-associated post-transcriptional regulation.
Biological function: Protein argonaute-1 binds microRNAs (miRNAs) and small interfering RNAs (siRNAs) and uses their sequence information to recognize complementary RNA targets. AGO1 supports RNA interference and RNA silencing, including translational repression and degradation of miRNA-bound mRNA targets; NCBI also describes a role in transcriptional gene silencing of complementary promoter regions.
