Primärantikörper geliefert von Boster Bio
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Ermöglicht die S100-Protein-Bindungsaktivität, die Bindungsaktivität von fortgeschrittenen Glykationsendprodukten und die Heparin-Bindungsaktivität. Beteiligt an verschiedenen Prozessen, einschließlich der zellulären Reaktion auf Amyloid-Beta; der negativen Regulation der Langzeitpotenzierung von Synapsen; und der positiven Regulation der Zytokinproduktion. Wirkt vorgelagert oder innerhalb mehrerer Prozesse, einschließlich der Induktion von positiver Chemotaxis; der negativen Regulation der Rezeptoraktivität von fortgeschrittenen Glykationsendprodukten; und der positiven Regulation des Makromolekül-Stoffwechselprozesses. Befindet sich im extrazellulären Raum und in der Plasmamembran. Wird in verschiedenen Strukturen exprimiert, darunter im Verdauungssystem; Gehirn; Urogenitalsystem; hemolymphatischen Drüsensystem; und in der Lunge. Menschliche Orthologe dieses Gens sind an mehreren Krankheiten beteiligt, darunter Autoimmunerkrankungen (mehrere); Herz-Kreislauf-Erkrankungen (mehrere); Mukoviszidose; Nierenversagen (mehrere); und Lupusnephritis. Ortholog zu humanem AGER (Rezeptor für fortgeschrittene Glykosylierungs-Endprodukte).
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Maus | ||||||||
| Ratte |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
AGER is the advanced glycosylation end-product specific receptor, commonly known as RAGE. It is a multiligand cell-surface receptor that senses advanced glycation end products and other endogenous stress-associated ligands, linking extracellular stress signals to inflammatory cellular responses.
Biological function: AGER/RAGE is an immunoglobulin-superfamily pattern-recognition receptor that binds multiple structurally diverse ligands, including advanced glycation end products, S100 proteins and HMGB1. Ligand engagement activates intracellular signalling programmes that can include NF-kappa-B and other inflammatory pathways, allowing cells to respond to tissue stress and damage-associated signals.
