Primärantikörper geliefert von Boster Bio
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Das von diesem Gen kodierte Protein ist ein bifunktionelles, zytosolisches Protein, das als essenzielles Enzym im TCA-Zyklus fungiert und mit mRNA interagiert, um den Eisenspiegel in Zellen zu kontrollieren. Wenn die zellulären Eisenwerte hoch sind, bindet dieses Protein an einen 4Fe-4S-Cluster und fungiert als Aconitase. Aconitasen sind Eisen-Schwefel-Proteine, die die Umwandlung von Citrat zu Isocitrat katalysieren. Wenn die zellulären Eisenwerte niedrig sind, bindet das Protein an Eisen-responsive Elemente (IREs), die Stamm-Schleifen-Strukturen sind, die in der 5'-UTR der Ferritin-mRNA und in der 3'-UTR der Transferrinrezeptor-mRNA gefunden werden. Wenn das Protein an IRE bindet, führt dies zu einer Repression der Translation der Ferritin-mRNA und einer Hemmung des Abbaus der ansonsten schnell abgebauten Transferrinrezeptor-mRNA. Das kodierte Protein wurde aufgrund seiner Fähigkeit, mechanistisch unterschiedliche Funktionen auszuführen, als Moonlighting-Protein identifiziert. Alternatives Spleißen führt zu mehreren Transkriptvarianten.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
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This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Aconitase 1 (ACO1), also known as cytoplasmic aconitate hydratase and iron regulatory protein 1 (IRP1), is a bifunctional human protein linking citrate metabolism with iron-responsive post-transcriptional regulation.
Biological function: ACO1 is a bifunctional cytosolic protein. When assembled with a [4Fe-4S] cluster it acts as aconitase, catalysing the reversible interconversion of citrate and isocitrate through cis-aconitate. Under iron-limiting conditions, loss of the cluster enables ACO1/IRP1 to bind iron-responsive elements in target mRNAs and regulate proteins involved in cellular iron uptake, storage and use.
