Primärer Antikörper geliefert von Boster Bio
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Das von diesem Gen kodierte Protein gehört zur Familie der Angiotensin-Converting-Enzyme der Dipeptidyl-Carboxydipeptidasen und weist eine erhebliche Homologie zum humanen Angiotensin-1-konvertierenden Enzym auf. Dieses sezernierte Protein katalysiert die Spaltung von Angiotensin I in Angiotensin 1-9 und von Angiotensin II in den Vasodilatator Angiotensin 1-7. ACE2 ist dafür bekannt, in verschiedenen menschlichen Organen exprimiert zu werden, und seine organ- und zellspezifische Expression deutet darauf hin, dass es eine Rolle bei der Regulierung der Herz-Kreislauf- und Nierenfunktion sowie der Fruchtbarkeit spielen könnte. Darüber hinaus ist das kodierte Protein ein funktioneller Rezeptor für das Spike-Glykoprotein des humanen Coronavirus HCoV-NL63 und der humanen Coronaviren des schweren akuten respiratorischen Syndroms, SARS-CoV und SARS-CoV-2, wobei letzteres der Erreger der Coronavirus-Krankheit-2019 (COVID-19) ist. Es wurden mehrere Spleißvarianten für dieses Gen gefunden, und die dACE2- (oder MIRb-ACE2) Spleißvariante wurde als Interferon-induzierbar identifiziert.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Angiotensin-converting enzyme 2 (ACE2; also known as ACEH) is a membrane-associated metallopeptidase in the renin-angiotensin system. This target record connects human NCBI Gene 59272, reviewed UniProtKB Q9BYF1 and related ABMIUM catalogue products.
Biological function: Angiotensin-converting enzyme 2 (ACE2) is a counter-regulatory carboxypeptidase of the renin-angiotensin system. It converts angiotensin I to angiotensin-(1-9) and angiotensin II to angiotensin-(1-7), helping counterbalance classical angiotensin II signalling and supporting cardiovascular homeostasis. ACE2 also functions as a cellular receptor for HCoV-NL63, SARS-CoV and SARS-CoV-2 spike proteins.
