Recombinant Human PTHrP protein, 15N

Background

Parathyroid Hormone-like related Protein (PTHrP) is a member of the Parathyroid hormone family that is expressed in the mammary gland. It is known as a potent inhibitor of chondrocyte maturation. PTHrP is expressed by periarticular perichondrial cells and exerts its biological activity on PP-R expressing cells. During endochondral bone development PTHrP plays a major role in suppressing the onset of hypertrophic differentiation. PTHrP plays a central role in regulating the extracellular concentrations of calcium and phosphorous and it is responsible for most cases of humoral hypercalcemia of malignancy.

Expression system

Escherichia coli.

Purity

> 97 % by SDS-PAGE and HPLC analyses.

Molecular weight

Approximately 10033 Da, a single non-glycosylated polypeptide chain containing 86 amino acids. 15N stable isotope labeled.

Endotoxin

Less than 0.1 EU/μg of rHuPTHrP, 15N as determined by LAL method.

Form

Sterile Filtered White lyophilized (freeze-dried) powder. Formulation Lyophilized from a 0.2 μm filtered concentrated solution in 10 mM PB, pH 6.0, 300 mM NaCl.

Packaging image shown for reference. Select a size from the available options.