Human Interleukin-31 Receptor Subunit Alpha, IL31RA ELISA Kit

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Human Interleukin-31 Receptor Subunit Alpha, IL31RA ELISA Kit

Human Interleukin-31 Receptor Subunit Alpha, IL31RA ELISA Kit

SKU:
ABM216802
Manufacturer SKU
E5522Hu
Product type
ELISA Kits
TargetIL31RA
ApplicationsELISA
Species / reactivityHuman
Sample typeSerum, Plasma, Cell culture supernatants, Ascites, Tissue homogenates

Manufacturer provenance

Manufactured by:
BT LAB
Sold by:
ABMIUM
Fulfilled from:
Manufacturer facility or confirmed fulfilment location

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Product description

Background

Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 (PubMed: 11877449, PubMed: 14504285, PubMed: 15627637, PubMed: 15194700). May function in skin immunity (PubMed: 15184896). Mediates IL31-induced itch, probably in a manner dependent on cation Channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity).

Test principle

This kit is an Enzyme-Linked Immunosorbent Assay (ELISA). The plate has been pre-coated with Human IL31RA antibody. IL31RA present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human IL31RA Antibody is added and binds to IL31RA in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated IL31RA antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human IL31RA. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Key facts & specifications
Research areas
Immunology
Also known as
Cytokine receptor-like 3;GLM-R;Gp130-like monocyte receptor;Gp130-like receptor;hGLM-R;IL 31;IL-31 receptor subunit alpha;IL-31R subunit alpha;IL31RA;IL-31RA;IL-31R-alpha;Interleukin-31 receptor subunit alpha;ZcytoR17;
Assay type
Sandwich
Detection method
Colorimetric (450 nm)
Sensitivity
1.34ng/L
Detection range
3-900ng/L
Plate format
Pre-coated ELISA plate
Assay duration
1h 30m
Molecular weight
82,954 Da
Quantity per pack
48T, 96T
Validation & performance evidence
ABMIUM Validated™ ABMIUM Verified™ Expected performance Not suitable

Application validation matrix

Evidence status by application and model.

EvidenceSerumPlasmaCell culture supernatantsAscitesTissue homogenates
Compatibility
Identifiers & database references
Manufacturer SKU
E5522Hu
Gene symbol
IL31RA
Gene ID
133396
UniProt accession
Q8NI17
Storage, stability & shipping
Shelf life
Store at -20°C for one year. Or store at 2-8°C for 6 months. If individual reagents are opened it is recommended that the kit be used within 1 month. Avoid repeated thaw cycles. *This product is for research use only, not for use in diagnosis procedures. It’s highly recommended to read this instruction entirely before use.
Storage conditions
2-8ºC
Compliance & documents
Datasheet
Open datasheet
Product manual
Open manual
Frequently asked questions
Who manufactured this product?

This product is manufactured by BT LAB and sold through ABMIUM without relabelling.

Can ABMIUM ship this product internationally?

ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.

Can I check suitability before ordering?

Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.

Is this product for clinical use?

Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.

BT LAB
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