Human S100 calcium binding protein A8/A9, S100A8/A9 ELISA Kit
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S100A9: Secreted. Cytoplasm. Cytoplasm > cytoskeleton. Cell membrane. Associates with tubulin filaments in activated monocytes. Targeted to the cell surface upon calcium influx. Released from blood leukocytes upon exposure to CSF2/GM-CSF, bacterial lipopolysaccharide (LPS) and during inflammatory processes. Serum levels are high in patients suffering from chronic inflammation. S100A8: Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation or endothelial adhesion of monocytes, is secreted via a microtubule-mediated, alternative pathway.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | Serum | Plasma | Urine | Ascites | Cerebrospinal fluid | Tissue | Cell culture supernatants | Tissue homogenates |
|---|---|---|---|---|---|---|---|---|
| Compatibility |
This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
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S100A8 identifies S100 calcium binding protein A8 in Homo sapiens (Human). This target record connects NCBI Gene 6279, UniProtKB P05109 and related ABMIUM catalogue products.
Biological function: S100 calcium binding protein A8 (S100A8; MRP8/S100-A8) is a calcium-binding S100-family protein with two EF-hand motifs. Curated functional annotations support roles in inflammatory signalling, including binding to RAGE and Toll-like receptor 4.
