Mouse Nad-dependent Protein Deacetylase Sirtuin-3, SIRT3 ELISA Kit
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NAD-dependent protein deacetylase (PubMed: 23835326, PubMed: 17923681, PubMed: 18794531, PubMed: 21172655, PubMed: 26620563). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed: 23835326, PubMed: 17923681, PubMed: 18794531, PubMed: 21172655). Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP Synthase subunit ATP5PO (PubMed: 16790548, PubMed: 18794531, PubMed: 21172655). Contributes to the regulation of the cellular energy metabolism (PubMed: 23835326). Important for regulating tissue-specific ATP levels (PubMed: 18794531, PubMed: 24252090). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed: 23283301). Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide Synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (PubMed: 26620563).
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | Serum | Plasma | Cell culture supernatants | Ascites | Tissue homogenates |
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
SIRT3 identifies sirtuin 3 in Homo sapiens (Human). This target record connects NCBI Gene 23410, UniProtKB Q9NTG7 and related ABMIUM catalogue products.
