ATG7 Rabbit Polyclonal Antibody
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This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
ATG7 (autophagy related 7) encodes ubiquitin-like modifier-activating enzyme ATG7, an E1-like enzyme that drives the ATG12-ATG5 and ATG8/LC3 conjugation systems required for autophagosome formation. ABMIUM catalogue products linked below target ATG7; suitability remains product- and application-specific.
Biological function: ATG7 acts as the E1-like activating enzyme for two core autophagy conjugation pathways. It activates ATG12 for conjugation to ATG5 and activates ATG8-family proteins for phosphatidylethanolamine conjugation, supporting LC3 lipidation and autophagosomal membrane formation. Reviewed UniProt also supports a role in mitophagy and mitochondrial quality control.
