PPBI Polyclonal Antibody
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There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of bacterial translocation in the gut.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Alkaline phosphatase, intestinal (ALPI), commonly called intestinal alkaline phosphatase (IAP), is a brush-border phosphomonoesterase expressed in the intestine. It is studied for its digestive phosphatase activity and its contribution to gut mucosal defence, including dephosphorylation of microbial products such as lipopolysaccharide.
Biological function: Intestinal-type alkaline phosphatase (ALPI/IAP) hydrolyses phosphate monoesters and functions as a digestive brush-border enzyme. Authoritative records also support a role in gut mucosal defence, including detoxification of lipopolysaccharide and limitation of bacterial translocation.
