MIS Polyclonal Antibody
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This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
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AMH (anti-Mullerian hormone; anti-Muellerian hormone) is a secreted TGF-beta-superfamily ligand also known as Mullerian-inhibiting substance (MIS). It signals through AMHR2 and downstream SMAD pathways in reproductive development and gonadal biology.
Biological function: AMH is synthesized as a preproprotein and proteolytically processed into an active ligand complex. It binds the type-II receptor AMHR2, which recruits type-I receptors including ACVR1 and BMPR1A to activate SMAD signalling. During male fetal development this pathway drives Mullerian duct regression; AMH also contributes to Leydig-cell and ovarian follicle biology.
