SERCA2 Polyclonal Antibody
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ATP2A2 encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
ATP2A2 encodes SERCA2, a sarcoplasmic/endoplasmic-reticulum calcium pump that uses ATP hydrolysis to move cytosolic calcium into intracellular stores. This target record connects the human ATP2A2/SERCA2 reference identifiers with ABMIUM catalogue products targeting SERCA2.
Biological function: ATP2A2/SERCA2 is a magnesium-dependent calcium-transporting ATPase. It couples ATP hydrolysis to movement of Ca2+ from the cytosol into the sarcoplasmic or endoplasmic reticulum lumen, helping maintain intracellular calcium stores and calcium homeostasis. The reviewed UniProt record also supports roles in starvation-induced autophagy and regulation of endoplasmic-reticulum contact sites.
