MASP1 Rabbit Polyclonal Antibody
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enzyme regulation:Inhibited by SERPING1 and A2M.|Functions in the lectin pathway of complement| which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.|PTM:Autoproteolytic processing of the proenzyme produces the active enzyme composed on the heavy and the light chain held together by a disulfide bond. Isoform 1 but not isoform 2 is activated through autoproteolytic processing.|PTM:N-glycosylated. Some N-linked glycan are of the complex-type.|PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.|Belongs to the peptidase S1 family.|Contains 1 EGF-like domain.|Contains 1 peptidase S1 domain.|Contains 2 CUB domains.|Contains 2 Sushi (CCP/SCR) domains.|subunit:Homodimer. Interacts with the oligomeric lectins MBL2| FCN2 and FCN3; triggers the lectin pathway of complement through activation of C3. Interacts with SERPING1.|tissue specificity:Protein of the plasma which is primarily expressed by liver.|
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | WB | ELISA |
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
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