GDF-15 Polyclonal Antibody
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Growth/differentiation factor 15 encoded by GDF15 belongs to the transforming growth factor-beta (TGF-beta) family. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress reponse program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
GDF15 identifies growth differentiation factor 15 in Homo sapiens (Human). This target record connects NCBI Gene 9518, UniProtKB Q99988 and related ABMIUM catalogue products.
Biological function: GDF15 is a secreted stress-responsive hormone/cytokine that communicates physiological stress to the brain. It binds GFRAL and forms a signalling complex with RET in brainstem neurons, producing responses that include reduced food intake and altered energy balance; circulating GDF15 is also widely studied in metabolic stress, pregnancy, cancer and cachexia.
