FoxO4 (Acetyl Lys407) Rabbit Polyclonal Antibody
Know who made it. See the evidence. Buy through one marketplace.
disease:A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X;11)(q13;q23) with MLL/HRX. The result is a rogue activator protein.|Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.|pharmaceutical:A constitutively active FOXO4 mutant where phosphorylation sites Thr-32| Ser-187 and Ser-262 have been mutated to alanine may have therapeutic potential in ERBB2/HER2-overexpressing cancers as it inhibits ERBB2-mediated cell survival| transformation and tumorigenicity.|PTM:Acetylation by CBP| which is induced by peroxidase stress| inhibits transcriptional activity. Deacetylation by SIRT1 is NAD-dependent and stimulates transcriptional activity.|PTM:Phosphorylation by PKB/AKT1 inhibits transcriptional activity and is responsible for cytoplasmic localization.|Contains 1 fork-head DNA-binding domain.|subcellular location:When phosphorylated| translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation.|subunit:Interacts with CBP| MYOCD| SIRT1| SRF and YWHAZ. Acetylated by CBP and deacetylated by SIRT1. Binding of YWHAZ inhibits DNA-binding.|tissue specificity:Heart| brain| placenta| lung| liver| skeletal muscle| kidney and pancreas. Isoform zeta is most abundant in the liver| kidney| and pancreas.|
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | WB | ELISA |
|---|---|---|
| Applications |
This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
FOXO4 identifies forkhead box O4 in Homo sapiens (Human). This target record connects NCBI Gene 4303, UniProtKB P98177 and related ABMIUM catalogue products.
