BID (Cleaved-Arg71) Rabbit Polyclonal Antibody
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Intact BH3 motif is required by BIK| BID| BAK| BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.|The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1| isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.|PTM:Phosphorylated upon DNA damage| probably by ATM or ATR.|PTM:TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products.|subcellular location:A significant proportion of isoform 2 localizes to mitochondria| it may be cleaved constitutively.|subcellular location:Associated with the mitochondrial membrane.|subcellular location:Translocates to mitochondria as an integral membrane protein.|subcellular location:When uncleaved| it is predominantly cytoplasmic.|subunit:Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2.|tissue specificity:Isoforms 2 and 3 are expressed in spleen| bone marrow| cerebral and cerebellar cortex. Isoform 2 is expressed in spleen| pancreas and placenta (at protein level). Isoform 3 is expressed in lung| pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level).|
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | WB | ELISA |
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
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Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
BID identifies BH3 interacting domain death agonist in Homo sapiens (Human). This target record connects NCBI Gene 637, UniProtKB P55957 and related ABMIUM catalogue products.
