AIM2 Polyclonal Antibody
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AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
AIM2 is absent in melanoma 2, also known as interferon-inducible protein AIM2. It is a cytosolic double-stranded DNA sensor and core component of the AIM2 inflammasome, linking detection of misplaced DNA to innate inflammatory responses.
Biological function: AIM2 binds cytosolic double-stranded DNA through its HIN domain and assembles an inflammasome with the adaptor ASC, enabling caspase-1 activation. This promotes maturation of inflammatory cytokines and gasdermin-dependent pyroptotic cell death as part of innate defence against cytosolic DNA.
