ABMIUM target intelligence
ATM serine/threonine kinase
ATM (ATM serine/threonine kinase), also known as serine-protein kinase ATM and A-T mutated, is a central DNA-damage-response kinase activated by DNA double-strand breaks. It coordinates checkpoint signaling and genome-stability responses while ABMIUM products below provide catalogue-backed reagents for ATM research.
Read full target overview![Anti-Human/Mouse/Rat Atm Antibody [B548] - ABMIUM](http://www.abmium.com/cdn/shop/files/mpW9uYDq.jpg?v=1781564388&width=520)
![Anti-Human/Mouse/Rat Atm Antibody [B894] - ABMIUM](http://www.abmium.com/cdn/shop/files/kOIiFaZ0.jpg?v=1781565893&width=520)
Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
ATM is a large serine/threonine protein kinase that functions as a DNA damage sensor and signaling hub. Following DNA double-strand breaks and other genotoxic stresses, ATM phosphorylates downstream checkpoint and repair factors to coordinate cell-cycle control, DNA repair, chromatin responses and stress signaling.
ATM is studied in DNA double-strand-break signaling, checkpoint activation, genome stability, radiosensitivity, oxidative and genotoxic stress, and DNA-repair pathway experiments. Results can depend on damage stimulus, phosphorylation state, time point, cell-cycle context and assay format, so product-level validation should be matched to the experimental question.
Names used across publications, databases and supplier catalogues.
