ElabscienceABMIUM Verified™
Anti-Mensch/Maus/Ratte APEX1 Antikörper
SKU: ABM3031-1Primärantikörper
- Target
- APEX1
- Reactivity
- Mensch, Maus, Ratte
- Applications
- WB
- Host
- Kaninchen
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Available to orderABMIUM target intelligence
apurinic/apyrimidinic endodeoxyribonuclease 1
APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1; APE1/Ref-1) is the major human AP endonuclease and a multifunctional DNA-repair and redox regulator. It repairs abasic sites in base-excision repair and helps regulate redox-sensitive transcription-factor activity.
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Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
APEX1 cleaves the DNA phosphodiester backbone immediately 5′ to apurinic/apyrimidinic sites generated spontaneously or during base-excision repair, creating DNA ends for downstream repair. Reviewed UniProt also supports a redox-regulatory role toward transcription factors, linking genome maintenance with oxidative-stress signalling.
APEX1, also widely searched as APE1 or Ref-1, is studied in base-excision repair, oxidative DNA damage, genome stability and redox control of transcriptional responses. ABMIUM catalogue links indicate available research products for this target; researchers should confirm application- and species-specific validation on the individual product record.
Names used across publications, databases and supplier catalogues.