Human PCSK9 ELISA Kit EZ-Set™ (DIY Antibody Pairs)
ELISA Antibody Pair supplied by Boster Bio Read more ›
Product Description
Proprotein convertase subtilisin/kexin type 9, also known as PCSK9, is an enzyme that in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. By genomic sequence analysis, the PCSK9 gene was mapped to chromosome 1p32. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. Reduced LDLR levels result in decreased metabolism of low-density lipoproteins (LDL), which could lead to hypercholesterolemia. PCSK9 may also have a role in the differentiation of cortical neurons.
Product information
| Supplier | Boster Bio |
|---|---|
| ABMIUM evidence status | ABMIUM Verified™ collaborator-tested data |
| Catalogue reference | EZ1147 |
| Product category | EZ-Set™ ELISA Kits (Ab Pairs) |
| Reactive species | Human |
| Tested applications | ELISA |
| Gene name | PCSK9 |
| Protein name | Proprotein convertase subtilisin/kexin type 9 |
| Sample type | cell culture supernatants, serum and plasma ( heparin, EDTA, citrate). |
| Assay range | 156 pg/ml - 10,000 pg/ml |
| Specificity | Natural and recombinant human PCSK9 |
| Immunogen | Expression system for standard: NS0; Immunogen sequence: S153-Q692 |
| Storage | Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.) |
| UniProt | Q8NBP7 |
| NCBI Gene ID | 255738 |
Available variants
| Conjugation | Size |
|---|---|
| Not applicable | 5 plates/kit |
Key Facts
| Target | Proprotein convertase subtilisin/kexin type 9 |
| Also known as | FH3; HCHOLA3; LDLCQ1; NARC 1; NARC1; PC9; PCSK9; Proprotein convertase 9 |
| Species reactivity | Human |
| Purity | Natural and recombinant human PCSK9 |
| Shelf life | Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.) |
| Detection range | 156 pg/ml - 10,000 pg/ml |
| Sample types |
cell culture supernatantsserum and plasma ( heparinEDTAcitrate).
See sample validation ›
|
Sample Type Validation
4 sample types| Sample Type | SERUM | PLASMA (EDTA) | URINE | CSF | CELL SUPERNATANT |
|---|---|---|---|---|---|
| cell culture supernatants | |||||
| serum and plasma ( heparin | |||||
| EDTA | |||||
| citrate). |
Specifications
Storage & Stability
Compliance & Certifications
Not intended for diagnostic or therapeutic use.