Human LDLR ELISA Kit PicoKine®

Human LDLR ELISA Kit PicoKine® (96 Tests). Quantitate Human LDLR in cell culture supernatants, serum, plasma (heparin) and urine. Sensitivity: 12pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.

The Low-Density Lipoprotein (LDL) Receptor is a mosaic protein of 839 amino acids (after removal of 21-amino acid signal peptide) that mediates the endocytosis of cholesterol-rich LDL. In humans, the LDL receptor protein is encoded by the LDLR gene. It belongs to the Low density lipoprotein receptor gene family. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

Product information

Supplier	Boster Bio
ABMIUM evidence status	ABMIUM Verified™ collaborator-tested data
Catalogue reference	EK1542
Product category	PicoKine® ELISA Kits
Reactive species	Human
Tested applications	ELISA
Gene name	LDLR
Protein name	Low-density lipoprotein receptor
Sample type	cell culture supernatants, serum, plasma (heparin) and urine.
Assay range	62.5 pg/ml - 4,000 pg/ml
Sensitivity	<12 pg/ml
Specificity	Natural and recombinant human LDLR
Immunogen	Expression system for standard: NS0; Immunogen sequence: A22-R788
Storage	Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
UniProt	P01130
NCBI Gene ID	3949

Available variants

Conjugation	Size
Not applicable	96 wells/kit, with removable strips.