Human ERBB3/Her3 ELISA Kit PicoKine®

Human ERBB3/Her3 ELISA Kit PicoKine® is a research-use ELISA kit from Boster Bio for measuring Receptor tyrosine-protein kinase erbB-3 in Cell culture supernatant, Cell lysates, serum and plasma (heparin, EDTA). samples from Human. Use the listed assay range, sample guidance and protocol documents to assess suitability for the intended study.

Human ERBB3/Her3 ELISA Kit PicoKine® (96 Tests). Quantitate Human ERBB3 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.

Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene. ErbB3 has been shown to bind the ligands heregulin and NRG-2. Ligand binding causes a change in conformation that allows for dimerization, phosphorylation, and activation of signal transduction. ErbB3 can heterodimerize with any of the other three ErbB family members. The theoretical ErbB3 homodimer would be non-functional because the kinase-impaired protein requires transphosporylation by its binding partner to be active. Unlike the other ErbB receptor tyrosine kinase family members which are activated through autophosphorylation upon ligand binding, ErbB3 is found to be kinase impaired, having only 1/1000th the autophosphorylation activity of EGFR and no ability to phosphorylate other proteins. Therefore, ErbB3 must act as anallosteric activator.

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