CNG-1 rabbit pAb from ELK Biotechnology Read more ›
CNG-1 rabbit pAb is a research-use antibody from ELK Biotechnology for studying CNG-1 in WB, ELISA workflows with listed reactivity for Human, Mouse, Rat. Specifications and supporting documents below should be reviewed when planning the experiment.
The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008],
| Specificity | CNG-1 Polyclonal Antibody detects endogenous levels of CNG-1 protein. |
|---|---|
| Validation evidence captions | Western Blot analysis of HepG2 cells using CNG-1 Polyclonal Antibody | Western blot analysis of CNGA1 Antibody. The lane on the right is blocked with the CNGA1 peptide. | Western blot analysis of the lysates from HepG2 cells using CNGA1 antibody. |
| Collaborator | ELK Biotechnology |
| Partner model | ES4717 |
| Target | CNG-1 |
| Research areas | >>cGMP-PKG signaling pathway, >>cAMP signaling pathway, >>Phototransduction |
| Reactivity | Human,Mouse,Rat |
| Applications | WB,ELISA |
| Conjugation | Unconjugated |
| Dilution range | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CNGA1. AA range:401-450 |
| Concentration | 1 mg/ml |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Assay type | Antibody validation/application |
| Expression system | Rod cells in the retina. |
| Purity | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Species | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Human | |||||||
| Mouse | |||||||
| Rat |
| Species | Dilution | Notes |
|---|---|---|
| Human | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. | — |
| Mouse | — | — |
| Rat | — | — |
| Species | Dilution | Notes |
|---|
Collaborator meets ABMIUM quality standards and overall product performance standards have been met.
Quality management certification.
For research applications. Not for diagnostic use.
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