ABM97985
NUMB rabbit pAb
ISO 9001|ABMIUM Verified™|Antibody
NUMB rabbit pAb from ELK Biotechnology Read more ›
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Product Description
NUMB rabbit pAb is an ELK Biotechnology antibody for research workflows involving NUMB.
Background
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],
Additional antibody information
| Specificity | NUMB Polyclonal Antibody detects endogenous levels of NUMB protein. |
|---|
Key Facts
Product type
Primary Antibody›
Target: NUMB
| Target | NUMB |
| Also known as | NUMB; Protein numb homolog; h-Numb; Protein S171 |
| Concentration | 1 mg/ml |
| Working concentration | WB 1:500-2000; IF/ICC 1:100-500;ELISA 1:5000-20000 |
| Species reactivity | Human;Mouse;Rat |
| Observed band | 70kD |
| Cellular localization | Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to perinuclear endosomes in an AAK1-dependent manner. . |
| Purity | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Form / buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Research area | >>Notch signaling pathway |
| Host species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Tested applications |
WBIFELISA |
| Dilution range | WB 1:500-2000; IF/ICC 1:100-500;ELISA 1:5000-20000 |
| Immunogen | Synthesized peptide derived from the Internal region of human NUMB. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
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Reactivity & Application Validation
3 speciess| Species | WB | IHC | IF | ELISA | IP | FCM | CHIP |
|---|---|---|---|---|---|---|---|
| Human | |||||||
| Mouse | |||||||
| Rat |
ABMIUM Validated™
WB
| Species | Dilution | Notes |
|---|---|---|
| Human | WB 1:500-2000; IF/ICC 1:100-500;ELISA 1:5000-20000 | — |
| Mouse | — | — |
| Rat | — | — |
ABMIUM Validated™
IF
| Species | Dilution | Notes |
|---|
ABMIUM Validated™
ELISA
| Species | Dilution | Notes |
|---|
Specifications
Target
NUMB
Also known as
NUMB; Protein numb homolog; h-Numb; Protein S171
Concentration
1 mg/ml
Working concentration
WB 1:500-2000; IF/ICC 1:100-500;ELISA 1:5000-20000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form / buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Host species
Rabbit
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Species reactivity
Human;Mouse;Rat
Tested applications
WBIFELISA
Immunogen
Synthesized peptide derived from the Internal region of human NUMB.
Observed band
70kD
Cellular localization
Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to perinuclear endosomes in an AAK1-dependent manner. .
Dilution range
WB 1:500-2000; IF/ICC 1:100-500;ELISA 1:5000-20000
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage & Stability
Long-term storage
-20°C/1 year
Storage conditions
-20°C/1 year
Storage buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Compliance & Certifications
ISO 9001
ISO 9001:2015 Certified
Manufactured under ISO 9001:2015 quality management standards.
RUO
For Research Use Only
Not intended for diagnostic or therapeutic use.
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