Vasohibin rabbit pAb from ELK Biotechnology
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Vasohibin rabbit pAb is a research-use antibody from ELK Biotechnology for studying Vasohibin in WB, ELISA workflows with listed reactivity for Human, Mouse, Rat. Specifications and supporting documents below should be reviewed when planning the experiment.
caution:Although probably secreted, it lacks a canonical signal sequence.,function:Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity.,induction:By VEGF.,PTM:2 major forms (42 and 36 kDa) and 2 minors (32 and 27 kDa) may be processed by proteolytic cleavage. The largest form (42 kDa) seems to be secreted and the other major form (63 kDa) seems to accumulate within the cells or pericellular milieu. Polypeptide consisting of Met-77 to Arg-318 may correspond to the 27 kDa form and that consisting of Met-77 to Val-365 may correspond to the 36 kDa form.,similarity:Belongs to the vasohibin family.,tissue specificity:Preferentially expressed in endothelial cells. Highly expressed in fetal organs. Expressed in brain and placenta, and at lower level in heart and kidney. Highly detected in microvessels endothelial cells of atherosclerotic lesions.,
| Specificity | Vasohibin Polyclonal Antibody detects endogenous levels of Vasohibin protein. |
|---|---|
| Validation evidence captions | Western Blot analysis of various cells using Vasohibin Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000 | Western blot analysis of VASH1 Antibody. The lane on the right is blocked with the VASH1 peptide. | Immunohistochemical analysis of paraffin-embedded human colon. 1,primary Antibody was diluted at 1:200(4° overnight). 2, EDTA pH 9.0 was used for antigen retrieval. 3 Reday to use Secondary antibody( catalog: RS0011) was used at 37°C, 30min | Immunohistochemical analysis of paraffin-embedded human brain. 1,primary Antibody was diluted at 1:200(4° overnight). 2, EDTA pH 9.0 was used for antigen retrieval 3 Reday to use Secondary antibody( catalog: RS0011) was used at 37°C, 30min |
Fully tested in-house by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Human | |||||||
| Mouse | |||||||
| Rat |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
